Predicting Patient Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: A Comparison of Measurable Residual Disease (MRD) Assessment by Digital Polymerase Chain Reaction and Conventional MRD
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
A research investigation into the efficacy of digital Polymerase Chain Reaction (dPCR) for monitoring measurable residual disease (MRD) during allogeneic hematopoietic stem cell transplantation, with a focus on predicting relapse in patients diagnosed with leukemia, myelodysplastic syndromes (MDS), and related hematological conditions.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:
• The presence of at least one fusion gene or hematological tumor-associated mutation detected at diagnosis by NGS or real-time PCR provided for posttransplant MRD monitoring.
• Neutrophil engraftment
• Received at least one MRD monitoring by digital PCR after HSCT
Locations
Other Locations
China
Peking University People's Hospital
RECRUITING
Beijing
Contact Information
Primary
Meng Lv, M.D,Ph.D
drlvmeng@163.com
+861088324637
Backup
Ya-zhen Qin, Ph.D
qin2000@aliyun.com
+861088324702
Time Frame
Start Date: 2024-01-08
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 300
Treatments
Acute Leukemia
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia
MDS or MDS/MPN
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and other subtypes of Myelodysplastic/Myeloproliferative Neoplasm
CML
Chronic Myeloid Leukemia
Related Therapeutic Areas
Sponsors
Leads: Peking University People's Hospital